Quercetin As A Natural Antiviral Agent Against Covid-19 Bioavailability Challenges And Nanoformulation Approaches.

Abstract

The Urgent Search For Potent Antiviral Drugs Has Been Spurred By The Worldwide Effects Of COVID-19. A Powerful Natural Substance With Antiviral, Anti-inflammatory, And Immunomodulatory Qualities Is Quercetin, A Polyphenol Obtained From Plants. Research Indicates That Quercetin Supports Host Immune Response While Interfering With Several Aspects Of The SARS-CoV-2 Life Cycle, Such As Viral Entry And Multiplication. Despite Its Potential For Treatment, Quercetin's Limited Bioavailability And Poor Water Solubility Prevent It From Being Used In Clinical Settings. Nanoformulation Technologies Have Been Developed To Improve Its Targeted Distribution, Stability, And Absorption In Order To Address These Issues. In Preclinical Models, Tactics Such Polymeric Nanoparticles, Nanoemulsions, And Liposomes Loaded With Quercetin Have Shown Better Pharmacokinetic Profiles And Antiviral Results.This Abstract Emphasizes The Two Main Areas Of Current Research: Comprehending The Antiviral Mechanisms Of Quercetin And Using Nanotechnology To Get Beyond Its Delivery Restrictions For Possible Use In COVID-19 Treatment.

Keywords