Formulation, Optimization And Evaluation Of Methotrexate Loaded Nanoemulgel For Enhancing Transdermal Delivery In Rheumatoid Arthritis

Abstract

The Preparation And Assessment Of A Topical Delivery System For Methotrexate-loaded Nanoemulgel For The Treatment Of Rheumatoid Arthritis Was The Goal Of This Investigation. METHODS: Using Peanut Oil, Tween 20 As The Surfactant, And PEG 400 As A Co-surfactant, The Pseudo Ternary Phase Diagram Was Produced Based On The Nanoemulsion Composition. The Methotrexate-loaded Nanoemulsion Was Made Using The Spontaneous Emulsification Technique. Badam Gum Was Used As A Gel Matrix In The Resulting Nanoemulsion To Create Nanoemulgel. The Methotrexate-loaded Nanoemulgel PH, Particle Size, Physical Appearance, Viscosity, Spreadability, TEM, Drug Content, Diffusion Studies, Release Kinetics, And Stability Investigations Were All Evaluated And Described. Nanoemulgel Was Clear And Had A Particle Size Of 19. RESULTS: A Nanoemulgel Comprising 8.6% Peanut Oil, 34.4% Tween 20 And PEG 400 As Smix (surfactant And Co-surfactant Mixture), 43% Water, And 12.5% W/w Badam Gum Was Shown To Be The Ideal Formulation. The Generated Nanoemulgel Had A 195.1 Nm Particle Size And A Zeta Potential Of -0.278 MV. Its Nature Was Transparent. The Drug Content And Release Of The Improved Formulation Were Determined To Be 98.11±0.34% And 95.11±0.02%, Respectively. The Optimal PH, Viscosity, And Spreadability Levels Were Found. The Results Of The Stability Analysis Showed That The Generated Nanoemulgel Remained Stable At Temperatures Between -25 And +45°C. In Conclusion, Methotrexate-loaded Nanoemulgel Has Been Successfully Created For Topical Drug Delivery In Rheumatoid Arthritis Treatment.

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