Formulation And Evaluation Of Stavudine Floating Tablet

Abstract

This Research Aims To Enhance The Gastric Retention Time Of Stavudine By Formulating Floating Matrix Tablets And Investigating The Effect Of Various Polymers On The Drug Release Profile. The Tablets Were Developed Using A Melt Granulation Technique, Incorporating Beeswax As The Hydrophobic Meltable Base. Hydroxypropyl Methylcellulose (HPMC) Served As The Matrix-forming Agent, Sodium Bicarbonate As The Gas-generating Component, And Ethyl Cellulose As The Floating Enhancer. The Final Formulations Were Assessed For Several Physical Parameters, Including Hardness, Weight Consistency, Friability, Buoyancy Characteristics (such As Lag Time And Duration Of Floating), Drug Content Uniformity, Stability, And In Vitro Release Behavior. Additionally, Interactions Between The Drug And Polymers Were Analyzed Using Differential Scanning Calorimetry (DSC) And Fourier Transform Infrared Spectroscopy (FT-IR).

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