Formulation And Evaluation Of Mucoadhesive Polymer Blend Prochlorperazine Maleate Tablet

Abstract

The Objective Of This Study Was To Develop And Evaluate A Mucoadhesive Polymer Blend-based Prochlorperazine Maleate Tablet For Enhanced Drug Retention And Controlled Drug Release. Prochlorperazine Maleate, A Dopamine Receptor Antagonist, Is Widely Used In The Treatment Of Nausea, Vomiting, And Schizophrenia. However, Its Conventional Dosage Forms Suffer From Limitations Such As Rapid Clearance And Reduced Bioavailability. To Overcome These Issues, A Mucoadhesive Tablet Formulation Was Developed Using Bioadhesive Polymers Like Carbopol 934P, Hydroxypropyl Methylcellulose (HPMC), Sodium Carboxymethyl Cellulose (NaCMC), And Chitosan. The Polymer Blend Was Optimized And Evaluated Based On Flow Properties, Swelling Index, Mucoadhesive Strength, Drug-polymer Interaction, In-vitro Drug Release, And Stability Studies. The Results Demonstrated That The Optimized Formulation Exhibited Good Mucoadhesion, Controlled Swelling, And Sustained Drug Release, Ensuring Prolonged Retention In The Buccal Cavity. The Drug Release Followed A Sustained-release Pattern, Enhancing Therapeutic Efficacy And Patient Compliance. This Study Highlights The Potential Of Mucoadhesive Drug Delivery Systems For Improving The Bioavailability And Effectiveness Of Prochlorperazine Maleate.

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