Formulation And Evaluation Of Floating Tablets Of Lamiuvdine

Abstract

The Present Study Focuses On The Formulation And Evaluation Of Controlled-release Floating Tablets Of Lamivudine, An Antiretroviral Drug Widely Used In The Management Of HIV/AIDS. Due To Its Short Half-life And Frequent Dosing Requirements, There Is A Need To Develop A Dosage Form That Can Enhance Paient Compliance, Improve Therapeutic Efficacy, And Sustain Drug Release Over An Extended Period. Floating Drug Delivery Systems Were Selected To Prolong The Gastric Residence Time Of The Dosage Form, Thereby Enhancing The Bioavailability Of Lamivudine, Which Is Primarily Absorbed From The Stomach And Upper Part Of The Gastrointestinal Tract. The Tablets Were Formulated Using The Wet Granulation Technique, Incorporating Hydrophilic Polymers Like Hydroxypropyl Methylcellulose (HPMC) And Ethylcellulose As Release-retarding Agents. Effervescent Agents Such As Sodium Bicarbonate And Citric Acid Were Added To Enable Floatation. Precompression Parameters (angle Of Repose, Carr’s Index, Hausner’s Ratio) And Post-compression Evaluations (hardness, Friability, Drug Content, Floating Lag Time, Total Floating Time, And In Vitro Drug Release) Were Conducted In Accordance With Standard Protocols. Among Various Formulations, The Optimized Batch Demonstrated Excellent Buoyancy For Over 12 Hours, Sustained Drug Release Up To 12 Hours, And Complied With All Physicochemical Parameters. FTIR Studies Confirmed The Absence Of Drug-excipient Interactions. The In Vitro Release Data Best Fitted The Korsmeyer-Peppas Kinetic Model, Indicating A Non-Fickian Diffusion-controlled Release Mechanism. In Conclusion, The Study Successfully Developed A Stable, Effective, And Controlled-release Floating Tablet Of Lamivudine, Which Holds Promise For Improved Patient Adherence And Better Man

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