Formulation And Evaluation Of Films For Buccal Drug Delivery System

Abstract

Buccal Films Represent A Promising Advancement In Oral Drug Delivery, Offering Several Benefits Over Conventional Dosage Forms. These Thin, Polymeric Strips Adhere To The Buccal Mucosa, Facilitating Direct Absorption Into Systemic Circulation And Effectively Bypassing First-pass Hepatic Metabolism, Which Enhances Bioavailability And Enables A Rapid Onset Of Action. Due To Their Ease Of Use, Absence Of A Need For Water During Administration, And Patient-friendly Design, Buccal Films Are Particularly Advantageous For Paediatric, Geriatric, And Dysphagic Populations. This Study Provides An Overview Of Buccal Film Classification, Advantages, Limitations, Packaging, And Manufacturing Methods, With A Focus On Solvent Casting And Hot-melt Extrusion. The Role Of Formulation Components—such As Film-forming Polymers, Plasticizers, Sweeteners, And Saliva Stimulants—is Discussed In Detail. BetaxololHCl, A Cardio Selective β1-adrenergic Blocker Used In Hypertension Treatment, Is Explored As A Model Drug For Buccal Delivery. Evaluation Parameters Including Film Thickness, Folding Endurance, Drug Content Uniformity, In Vitro Disintegration, And Dissolution Testing Are Described To Assess Film Quality And Performance. The Findings Affirm Buccal Films As An Efficient And Patient-compliant Platform For Non-invasive Drug Administration With Significant Clinical Potential.

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