Formulation And Evaluation Of Ciprofloxacin Hcl Effervescent Tablets For Enhanced Solubility And Patient Compliance

Abstract

This Research Focuses On The Formulation And Evaluation Of Ciprofloxacin HCl Effervescent Tablets To Enhance Solubility And Patient Compliance. Ciprofloxacin HCl Has Poor Aqueous Solubility, Leading To Delayed Dissolution And Reduced Bioavailability. Effervescent Formulations Improve Solubility, Taste, And Ease Of Administration, Making Them Ideal For Patients With Swallowing Difficulties. Effervescent Tablets Were Formulated Using Citric Acid And Sodium Bicarbonate As Effervescent Agents, Along With Solubility Enhancers, Sweeteners, And Disintegrants. Preformulation Studies, Including Solubility Analysis, Drug-excipient Compatibility (FTIR), And Powder Flow Properties, Were Conducted. The Optimized Formulation Exhibited Rapid Disintegration (2–3 Min), Enhanced Drug Release (>85% In 15 Min), And Stable Physicochemical Properties. The Study Confirms That Effervescent Ciprofloxacin HCl Tablets Offer Improved Solubility, Faster Onset Of Action, And Enhanced Patient Compliance, Making Them A Promising Alternative To Conventional Tablets, Especially For Pediatric And Geriatric Patients.

Keywords