Design And Characterization Of Naproxen Loaded Nanocrystal Gel

Abstract

The Present Study Aims To Design And Characterize Naproxen-loaded Nanocrystal Gel For Topical Application. Naproxen, A Non-steroidal Anti-inflammatory Drug (NSAID), Is Commonly Used For Pain Relief And Inflammation But Suffer From Poor Solubility And Gastric Side Effects When Taken Orally. To Overcome These Problems, Nanocrystals Of Naproxen Were Prepared Using The Antisolvent Precipitation Method Followed By High Pressure Homogenization, Which Helps To Reduce Particle Size And Improve Dissolution. The Prepared Nanocrystals Were Then Incorporated Into A Carbopol 940 Gel Base To Form A Smooth And Stable Nanocrystal Gel. The Nanocrystals Were Evaluated For Parameters Such As Particle Size, Calibration Curve And Zeta Potential. Nanocrystal Gel Was Evaluated For PH, Viscosity, Spreadability, Drug Content And Entrapment Efficiency. Zeta Potential And Particle Size Analysis Confirmed The Stability Of The Formulation. The Optimised Formulation (F3) Showed High Drug Content (92.3%) And High Entrapment Efficiency (99.9%), Confirming The Effectiveness Of Nanocrystal In Delivering Naproxen For Enhanced Therapeutic Outcomes. Hence, The Present Study Can Be Concluded That Naproxen Nanocrystal Formulation Is A Promising System For The Topical Delivery And It Enhances The Bioavailability By Improving The Solubility And Enhanced Bioavailability.

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