Calotropis Gigantea-enhanced Povidone Bandage: A Synergistic Approach For Wound Healing

Abstract

Wound Healing Is A Complex Biological Process Involving Inflammation, Cellular Proliferation, And Tissue Remodeling. Conventional Synthetic Wound Care Products Often Show Limited Effectiveness And May Cause Adverse Reactions. This Study Aimed To Develop And Evaluate Herbal-Based Adhesive Bandages Incorporating CalotropisGigantea Extract And Povidone Iodine As Natural Alternatives For Wound Management. Phytochemical Screening Revealed The Presence Of Bioactive Compounds Such As Alkaloids, Flavonoids, Tannins, Saponins, Terpenoids, And Cardiac Glycosides—Compounds Known For Their Antimicrobial And Healing Properties. Five Formulations (B1–B5) Were Assessed For Dermatological Safety, Organoleptic Characteristics, And Antimicrobial Activity Against Escherichia Coli, Staphylococcus Aureus, And Candida Species. All Formulations Were Found To Be Non-Irritant And Non-Allergenic. Organoleptic Evaluation Confirmed Acceptable Physical Properties, Including Uniform Spreadability And Characteristic Odour. Among The Samples, B3 Exhibited The Most Potent Antimicrobial Activity Across All Tested Organisms, Indicating Its Potential For Enhanced Wound Infection Control. These Findings Suggest That Herbal-Based Bandages Are Safe And Effective, Offering A Promising Natural Alternative For Improved Wound Care. Further In Vivo Studies Are Recommended To Validate These Results.

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