A Review On Various Herbal Plants And Behavioral Model’s On Parkinson’s Disease

Abstract

Parkinson’s Disease Is A Chronic Neurodegenerative Disorder With A Myriad Of Motor And Non-motor Symptoms. Its Management Is Essentially Palliative, And It Can Extend To Three To Four Decades. Device-assisted Therapy Including Deep Brain Stimulation, Apomorphine Pump, And Levodopa Gel Intestinal Infusion, Have Significantly Improved Management Of Advanced Parkinson’s Disease. The Condition Is Associated With Damage To The Dopaminergic Neurons Inthe Substantia Nigra Pars Compacta, A Great Decrement Of Dopamine Neurotransmitter In The Striatum, And A Deficiency Of Tyrosine Hydroxylase; The Rate-determining Enzyme During Dopamine Formation. Various Approaches , Including Genetic Manipulations And Toxin-induced Insults, Aim To Recapitulate Both Motor And Non-motor Aspects Of PD In Animal Models. Parkinson’s Disease (PD) Is The World’s Most Widespread Chronic Neuron Degenerative Motion Condition Affecting More Than 10 Million People. The Characteristic Hallmark Of PD Involves A Progressive Loss Of Dopaminergic Neurons In The Brain’s Substantial Nigra.

Keywords