Impact Factor
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Volume 12 Issue 07
July 2026
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Abstract
Human Immunodeficiency Virus (HIV) And Acquired Immunodeficiency Syndrome (AIDS) Continue To Represent A Major Global Health Challenge Despite Significant Advances In Antiretroviral Therapy (ART). Although ART Effectively Suppresses Viral Replication And Improves Patient Survival, It Does Not Provide A Definitive Cure And Requires Lifelong Adherence. In Recent Years, Genetically Modified Treatment Strategies Have Emerged As Promising Alternatives Aimed At Achieving Long-term Viral Control Or Functional Cure. This Review Focuses On The Current Progress And Potential Of Genetically Modified Therapies For The Treatment Of HIV/AIDS. The Approaches Discussed Include Gene Editing Technologies Such As CRISPR-Cas9, Zinc Finger Nucleases, And TALENs, Which Target Viral Genes Or Host Co-receptors Like CCR5 To Prevent Viral Entry. Additionally, Gene Therapy Strategies Involving Genetically Modified T Cells, Stem Cells, And Viral Vectors Are Explored For Their Ability To Enhance Immune Responses And Confer Resistance To HIV Infection. The Review Also Highlights The Advantages, Limitations, Safety Concerns, And Ethical Considerations Associated With These Advanced Therapies. Overall, Genetically Modified Treatments Represent A Revolutionary Direction In HIV/AIDS Management, Offering Hope For Durable Viral Suppression And Potential Cure, Although Further Clinical Studies Are Required To Establish Their Long-term Efficacy And Safety.
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Paper ID
IJSARTV11I12104458
Publication Date
December 27, 2025
Research Area
Review Article